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Rating: 
Summary: The truths about this book, as I know it.
Review: I consider myself fortunate to have had opportunities to study organic synthesis from some of the better contemporary organic chemists in the world. Here are some truths about it, regardless what was said in other comments.1) The book presents a dissection approach in organic synthesis; that is, starting with the target compound, students learn to "go backward", "simplify", hence "dissect" the compounds into several moeities (precursors), whose precursors, in turns, can be obtained by further dissections, and so on and so forth. The process is continued until simple, common, commercially available chemicals are recognized as precursors (or starting materials). The task is then to recreate the synthetic scheme(s) to prepare the target compound, starting with these commercially available chemicals. So the comments about the book on this approach are correct. 2) In order to recognize the precursors, and recreate the synthetic schemes, students DO HAVE TO KNOW AND REMEMBER ORGANIC REACTIONS AND RELEVANT REAGENTS before they can establish a reasonable and workable dissection. So the comment that thanks to this method, students can get away with memorizing numerous organic reactions, is INCORRECT. The dissection approach simply helps us to START WITH WHAT WE WANT TO MAKE, and SYSTEMATICALLY FIGURE OUT WHAT WE NEED TO HAVE AS STARTING MATERIALS. 3) Information in the book is somewhat outdated, due to rapidly increasing number of papers published in the field of organic synthesis. However, due to limited availability of textbooks that discuss the dissection approach in organic synthesis, this book is certainly a big help for students in chemistry and chemistry-related majors.
Rating: 
Summary: Retrosynthesis Primer
Review: The book treats the subject of organic retrosynthesis in a very clear fashion. It will be a perfect companion for students taking sunthetic organic chemistry course.
Rating:
Summary: Retrosynthesis Primer
Review: The book treats the subject of organic retrosynthesis in a very clear fashion. It will be a perfect companion for students taking sunthetic organic chemistry course.
Rating:
Summary: Retrosynthetic Analysis
Review: Warren's Organic Synthesis-Disconnection Approach focuses on retrosynthetic analysis in organic synthesis. Some of the central concepts introduced in this strategy book are synthons, target molecule, FGI (functional group interconversion), disconnection, and reagent. Synthons: an idealized fragment, usually a cation or an anion, resulting from a disconnection. Synthons may or may not be an intermediate in the corresponding reaction. Disconnection: the reverse operation to a reaction. The imagined cleavage of a bond to "break" the molecule into possible starting materials. Functional group interconversion: the process of converting one functional group into another by substitution, addition, elimination, oxidation, or reduction, and the reverse operation used in retrosynthetic analysis. Reagent: Warren introduces a formal and rigid definition of reagent in this book. Reagent is a compound used in practice for a synthon. Warren's treatise of organic synthesis emphasizes visualizing and choosing not only the most obvious but the most efficient disconnection (retrosynthesis) in synthesizing a target molecule. The book is set up in a fashion such that synthetic strategies and organic reactions are presented in alternating chapters. Strategies aim to enforce tricks and concepts of organic synthesis like stereoselectivity, control of regiochemistry and stereochemistry, control of carbonyl condensation, order of events in synthesis, rearrangements, use of ringed molecules. Reaction chapters present some of the most significant reactions in organic synthesis, with an emphasis of those involve carbon-carbon formation. Topics of Warren's Organic Synthesis:
Synthesis Strategies
-The Disconnection Approach
-The Order of Events
-Chemoselectivity
-Reversal of Polarity, Cyclization Reactions
-Protecting Groups
-Choosing a Disconnection (General Strategy)
-Stereoselectivity
-Regioselectivity
-Use of Acetylenes
-Introduction of Carbonyl Condensations
-Control in Carbonyl Condensations
-Use of Aliphatic Nitro Compounds in Synthesis
-Radical Reactions in Synthesis
-Reconnections
-Introduction to Ring Synthesis, Saturated Heterocycles
-Rearrangements in Synthesis
-Use of Ketenes in Synthesis
-Pericyclic Rearrangements in Synthesis
-Special Methods for 5-Membered Rings Reaction Methods
-One Group C-X Disconnections
-Two Group C-X Disconnections
-Amine Synthesis
-One Group C-C Disconnections: Alcohols
-One Group C-C Disconnections: Carbonyl Compounds
-Alkene Synthesis
-Two Group Disconnections: Diels-Alder Reactions
-Two Group Disconnections: 1,3-Difunctionalized Compounds and alpha,beta-unsaturated Carbonyl Compounds
-Two Group Disconnections: 1,5-Difunctionalized Compounds, Michael Addition, Robinson Annulation
-Two Group Disconnections: 1,2-Difunctionalized Compounds
-Two Group Disconnections: 1,4-Difunctionalized Compounds
-Two Group Disconnections: 1,6-Difunctionalized Compounds
-Three-Membered Rings
-Four-Membered Rings: Photochemistry in Synthesis
-Five-Membered Rings
-Six-Membered Rings
-Aromatic Heterocycles The book teaches retrosynthetic analysis in organic synthesis. The ability to recognize an obvious and/or obscure disconnection facilitates organic synthesis tremendously. The methods and strategies presented in Warren gives advanced undergraduate students, graduate students and practicing chemists an overview of the most significant retrosynthetic pathways. Exceptional work.
Rating:
Summary: Retrosynthetic Analysis
Review: Warren's Organic Synthesis-Disconnection Approach focuses on retrosynthetic analysis in organic synthesis. Some of the central concepts introduced in this strategy book are synthons, target molecule, FGI (functional group interconversion), disconnection, and reagent. Synthons: an idealized fragment, usually a cation or an anion, resulting from a disconnection. Synthons may or may not be an intermediate in the corresponding reaction. Disconnection: the reverse operation to a reaction. The imagined cleavage of a bond to "break" the molecule into possible starting materials. Functional group interconversion: the process of converting one functional group into another by substitution, addition, elimination, oxidation, or reduction, and the reverse operation used in retrosynthetic analysis. Reagent: Warren introduces a formal and rigid definition of reagent in this book. Reagent is a compound used in practice for a synthon. Warren's treatise of organic synthesis emphasizes visualizing and choosing not only the most obvious but the most efficient disconnection (retrosynthesis) in synthesizing a target molecule. The book is set up in a fashion such that synthetic strategies and organic reactions are presented in alternating chapters. Strategies aim to enforce tricks and concepts of organic synthesis like stereoselectivity, control of regiochemistry and stereochemistry, control of carbonyl condensation, order of events in synthesis, rearrangements, use of ringed molecules. Reaction chapters present some of the most significant reactions in organic synthesis, with an emphasis of those involve carbon-carbon formation. Topics of Warren's Organic Synthesis:
Synthesis Strategies
-The Disconnection Approach
-The Order of Events
-Chemoselectivity
-Reversal of Polarity, Cyclization Reactions
-Protecting Groups
-Choosing a Disconnection (General Strategy)
-Stereoselectivity
-Regioselectivity
-Use of Acetylenes
-Introduction of Carbonyl Condensations
-Control in Carbonyl Condensations
-Use of Aliphatic Nitro Compounds in Synthesis
-Radical Reactions in Synthesis
-Reconnections
-Introduction to Ring Synthesis, Saturated Heterocycles
-Rearrangements in Synthesis
-Use of Ketenes in Synthesis
-Pericyclic Rearrangements in Synthesis
-Special Methods for 5-Membered Rings Reaction Methods
-One Group C-X Disconnections
-Two Group C-X Disconnections
-Amine Synthesis
-One Group C-C Disconnections: Alcohols
-One Group C-C Disconnections: Carbonyl Compounds
-Alkene Synthesis
-Two Group Disconnections: Diels-Alder Reactions
-Two Group Disconnections: 1,3-Difunctionalized Compounds and alpha,beta-unsaturated Carbonyl Compounds
-Two Group Disconnections: 1,5-Difunctionalized Compounds, Michael Addition, Robinson Annulation
-Two Group Disconnections: 1,2-Difunctionalized Compounds
-Two Group Disconnections: 1,4-Difunctionalized Compounds
-Two Group Disconnections: 1,6-Difunctionalized Compounds
-Three-Membered Rings
-Four-Membered Rings: Photochemistry in Synthesis
-Five-Membered Rings
-Six-Membered Rings
-Aromatic Heterocycles The book teaches retrosynthetic analysis in organic synthesis. The ability to recognize an obvious and/or obscure disconnection facilitates organic synthesis tremendously. The methods and strategies presented in Warren gives advanced undergraduate students, graduate students and practicing chemists an overview of the most significant retrosynthetic pathways. Exceptional work.
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