Pharmacokinetic and Pharmacodynamic Data Analysis

Rating:
Summary: Gabrielsson's & Weiner's Pharmacokinetics & Pharmacodynamics
Review: This excellent review of PK and PD analysis might be envisioned as a merging of Rowland and Tozer's (clinical) and Gibaldi's resepective textbooks of pharmacokinetics. Although clearly written in support of the WinNonlin (Pharsight) analysis software (the second half of the book includes example models), the text is sufficient as a stand-alone by providing up to date, yet easily understandable and well illustrated discussion of pharmacokinetics. Both modeling and noncompartmental analysis are discussed, as is application of pharmacodynamic analysis. Clinical applicability is included. The book is useful for beginners as well as individuals who have been in the PK/PD business for a while. For myself and my graduate students, the book was particularly helpful in explaining the basis for "policies" followed by many published pharmacokinetic papers.