Handbook of Nucleoside Synthesis

Rating:
Summary: An overview of synthesis involving nucleoside glycosylation
Review: There are two general strategies for the synthesis of nucleoside analogues: 1)converting readily available nucleosides and 2)glycosylation of sugar with heterocyclic base. This book ONLY covers the latter one. The first 100 pages are an excellent discussion of synthetic methods to carry out the glycosylation reactions, along with plenty of actual examples. The next 500 pages or so (will anyone really read these? :-)are completely made of charts with records of past published synthesis. These charts list 'Sugar', 'Base' and 'conditions' used for each reaction, as well as the 'products' & 'yields' and ref. The book collected over 1300 reference titles overall and placed them at the end.
This handbook is a great rare-to-find reference in the field of glycosylation. However, do not expect to see all the aspects of nucleoside synthesis from it.